She was portrayed by Claire Coffee from October 5, to March 3, Nadine shows up at General Hospital in requesting to see her comatose sister Jolene. Damien Spinelli fills her in on Jolene's nefarious activities at GH. Nadine explains the two decided to become nurses after their father died on the operating table during a routine surgery. Nadine, dressed the same as Lulu, is mistaken for her and captured by Anthony Zacchara. Anthony threatens to kill her, but Spinelli helps her get away. She is the only one who knows that Nikolas sees Emily's ghost as an effect of the tumor.
Meanwhile, Nadine is drugged and kidnapped by Diego Alcazar but is able to survive. After learning that someone in Port Charles has been messing with the supply of counterfeit prescription drugs, Nadine, Nikolas, Lucky Spencer , and Sam McCall begin to investigate. Nadine believes that new doctor Matt Hunter is involved, but Nikolas thinks otherwise.
Nadine confides in Leyla Mir about her feelings for Nikolas. She ends up kissing him but is embarrassed afterwards, and tells Nikolas she does not want to hear the "friend" speech.
Nikolas admits to friend Elizabeth Webber that he's attracted to Nadine but feels like he would betray Emily's memory if he got involved with her. Elizabeth helps Nikolas to see that Emily would have wanted him to move on. Nikolas invites Nadine over and they have a romantic dinner together, ending the evening by dancing around the grounds. Nikolas seems to be falling in love with Nadine. In September , when the Emily Quartermaine clinic is burned down, injuring Nadine and Matt Hunter, he sits vigil by her side until she wakes up.
He insists that she come to Wyndemere Castle to recuperate. It is there that Nikolas tells Nadine that he is starting to fall in love with her. The night of Kate Howard 's shooting, Nikolas takes Nadine back to Wyndermere and they sleep together for the first time.
Nikolas and Nadine continue to spend more time together, and seem to be heading towards a relationship. When Nikolas is caught by the police while chasing after his mother Laura Spencer with his brother Lucky Spencer and sister Lulu Spencer , he was told he would be deported. Nadine offers to marry him and starts to make arrangements, until Nik reveals his lawyers have fixed the problem. Nadine receives news that her Aunt Rayleen is very ill and only has a short time to live.
Nadine and Nik visit Rayleen, and her last wish is for Nadine and Nik to get married. The couple pretend to be married so that Rayleen can die in peace. However, after Rayleen's death, Nadine receives an envelope containing the possessions Rayleen left her. It turns out she is now the new liaison with the government, who are doing business with weapon dealers. They need a crucial piece of information in order to finish their job.
Nadine refuses to give up the information, but eventually, Nik offers to take over her share and let his lawyers handle everything. They are both invited to the fundraiser for pediatric brain injuries in honor Michael Corinthos. Unfortunately, a man is brought into the hospital with spheres of airborne biotoxin in his body.
One bursts during surgery, causing the entire OR team to collapse, and the toxin to spread through the ventilating system into the board room of the hospital, where the fundraiser was being held. Eventually, Nadine is released from the board room and seems to be okay. However, later that night her heart is broken when she hears Nikolas tell Monica Quartermaine that he would never love anyone the way he loved Emily. Also later that night, Rebecca Shaw shows up in town, and is a deadringer of Emily.
Nikolas becomes obsessed with her. Nadine realizes Nik has never been in love with her the way she thought he was, and heartbroken, she breaks up with him. Nik wishes her "the best of luck" and Nadine does the same.